Throughout the biological and biomedical sciences there is a growing need for, prescriptive ‘minimum information’ (MI) checklists specifying the key information to include when reporting experimental results are beginning to find favor with experimentalists, analysts, publishers and funders alike. Such checklists aim to ensure that methods, data, analyses and results are described to a level sufficient to support the unambiguous interpretation, sophisticated search, reanalysis and experimental corroboration and reuse of data sets, facilitating the extraction of maximum value from data sets (...) them. However, such ‘minimum information’ MI checklists are usually developed independently by groups working within representatives of particular biologically- or technologically-delineated domains. Consequently, an overview of the full range of checklists can be difficult to establish without intensive searching, and even tracking thetheir individual evolution of single checklists may be a non-trivial exercise. Checklists are also inevitably partially redundant when measured one against another, and where they overlap is far from straightforward. Furthermore, conflicts in scope and arbitrary decisions on wording and sub-structuring make integration difficult. This presents inhibit their use in combination. Overall, these issues present significant difficulties for the users of checklists, especially those in areas such as systems biology, who routinely combine information from multiple biological domains and technology platforms. To address all of the above, we present MIBBI (Minimum Information for Biological and Biomedical Investigations); a web-based communal resource for such checklists, designed to act as a ‘one-stop shop’ for those exploring the range of extant checklist projects, and to foster collaborative, integrative development and ultimately promote gradual integration of checklists. (shrink)

The close proximity of the nineteenth century to our own age is an impediment in the way of tracing with confidence the lines of its intellectual development, and more especially of estimating the significance of its philosophical speculation. Certain characteristics of the latter are, however, already sufficiently obvious. It is clear, at any rate, that the chief attempts at philosophical construction in the nineteenth century were the outcome of German reflexion; it is clear also that the great thinker who died (...) in 1804 set the current of speculative activity upon a course markedly distinguishable from any that had been followed in preceding centuries. As a philosophical. (shrink)

English Philosophy owes much that is most characteristic of it to the assiduous toil of men whose vocation has not been that of academic teaching and research. Many of them have been engulfed in the routine of business life, and such hours as they could devote to philosophic reflexion have been snatched from intervals of leisure which the majority of business men relinquish to recreation and rest. The friend to whose memory I wish to pay my humble tribute would not (...) have claimed for himself, nor have permitted his associates to claim for him, the distinction of having initiated a new line of speculative reflexion. But, if he did not propound any original metaphysical theory, he possessed, in quite unusual measure, the. (shrink)

This year we have been celebrating our centenary, and, when so much has been said, and justly said, of the contributions to various branches of science and learning that have emanated from University College, it seems fitting that the part which the College has played in the advancement of philosophical research should not be left out of account. For in spite of the manifold difficulties that stood in the way of instituting a school of philosophical study in London, what has (...) been achieved here, both in the way of original investigation and of effective teaching, constitutes a record of which we may well be proud. (shrink)

As a powerful tool in the production of knowledge, comparing plays a crucial part in the sciences and the humanities. This volume explores the relationship between comparing and narrating in epistemic practices and clarifies the ways in which narratives enable or impede practices of comparing. It takes into account related activities, such as measuring and classifying, modeling, establishing norms and categories, as well as organizing and popularizing knowledge, to analyze the ambivalent relationship between narratives, scientific explanation, and understanding. The contributions (...) bring out the epistemic role of narratives, and elucidate how narratives are connected to comparisons and scientific explanations."--Publisher description. (shrink)

As coronavirus disease 2019 made its way across the world in 2019, health systems began to develop guidelines to allocate what was expected to be a scarcity of medical resources. Considerable attention was given to triaging intensive care resources such as ventilators. While there was general agreement among bioethicists and policymakers that it may be permissible to withhold life-sustaining interventions from patients with poor prognoses in order to make them available to patients with better prognoses, there was disagreement about the (...) permissibility of withdrawing such interventions for this purpose. Some maintained that the doctrine of double effect (DDE) revealed the intrinsic wrongness of such acts of reallocation. This article argues that so long as there is transparency and effective ongoing communication, the DDE may permit the discontinuation of life-sustaining interventions from patients who may still benefit from them in order to make them available to patients with more favorable prognoses. (shrink)

Why do we watch and like horror films? Despite a century of horror film-making and en-tertainment, little research has examined the human motivation to watch fictional horror and how horror film influences individuals’ behavioural, cognitive and emotional re-sponses. This review provides the first synthesis of the empirical literature on the psy-chology of horror film using multi-disciplinary research from psychology, psychotherapy, communication studies, development studies, clinical psychology, and media studies. The paper considers the motivations for people’s decision to watch horror, why (...) people enjoy horror, how individual differences influence responses to, and preference for, hor-ror film, how exposure to horror film changes behaviour, how horror film is designed to achieve its effects, why we fear and why we fear specific classes of stimuli, and how lik-ing for horror develops during childhood and adolescence. The literature suggests that (1) low empathy and fearfulness are associated with more enjoyment and desire to watch horror film but that specific dimensions of empathy are better predictors of people’s re-sponses than are others; (2) there is a positive relationship between sensation-seeking and horror enjoyment/preference but this relationship is not consistent; (3) men and boys prefer to watch, enjoy and seek our horror more than do women and girls; (4) women are more prone to disgust sensitivity or anxiety than are men and this may mediate the sex difference in the enjoyment of horror; (5) younger children are afraid of symbolic stimuli whereas older children become afraid of concrete or realistic stimuli; (6) in terms of coping with horror, physical coping strategies are more successful in younger children; priming with information about the feared object reduces fear and increases children’s enjoyment of frightening television and film. A number of limitations in the literature are identified, including the multifarious range of horror stimuli used in studies, disparities in methods, small sample sizes, and a lack of research on cross-cultural differences and similarities. Ideas for future research are explored. (shrink)

This paper is a reply to D'Costa's article ("Religious Studies," 32, pp. 223-32) in which he argues that there is no such position as religious pluralism because in distinguishing between, e.g., Christianity or Buddhism, and Nazism or the Jim Jones cult, a criterion is involved and to use a criterion is a form of exclusivism. In reply I point out that this sense of 'exclusivism', as consisting in the use of criteria, is self-destructive; that the pluralistic hypothesis, as a meta-theory (...) about the religions, has a different logical status from the creeds of the historical religions; and I also show the origin of the ethnical criterion used by the religious pluralist who stands within one or other of the great world faiths. (shrink)

To incorporate medical ethics into clinical practice, it must first be understood and valued by health care professionals. The recognition of this principle led to an expanding and continuing educational effort by the ethics committee of the Vancouver General Hospital. This paper reviews this venture, including some pitfalls and failures, as well as successes. Although we began with consultants, it quickly became apparent that education in medical ethics must reach all health care professionals—and medical students as well. Our greatest successes (...) came in the formative years of a medical career (ie, in medical school and residency training programmes), but other efforts were not wasted, particularly among nurses and other health care professionals.Although this is a personal review of the experience in one institution, the lessons learnt in Vancouver are applicable to the further development of medical ethics in the UK. (shrink)

Kant’s remark that the first Kritik should be read as a treatise on method rather than a system of doctrine lends support to recent forays against his theory of proof, for the comment promotes the mistaken supposition that his method can be studied independently of his commitments in ontology and other areas. Irony infects the criticisms in question because they set transcendental logic against a standard that Kant repudiates. The point will be illustrated by showing how Kant anticipates and blunts (...) a strong attack against his position on method. (shrink)

Taking a fresh view on Wittgenstein's apparent ethical skepticism, many contributions to this volume explore the reach of what can be said in ethical terms, while others provide critical discussions of what is being said in various fields of applied ethics and political philosophy under real-world power relations. This volume collects invited contributions from the 35th International Wittgenstein Symposium 2012 in Kirchberg am Wechsel, Austria.

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Due to the enormous disparity of power in the child welfare professional-client relationship, a high level of trust is necessary for this relationship to achieve its intended benefits, including protecting, caring for, terminating parental rights to, and finding appropriate adoptive homes for, abused and neglected children. This paper first defines conflicts of interest as necessarily including the exercise of judgment, and then argues that contractual relationships between private child welfare agencies and public departments of child welfare often betray their fiduciary (...) responsibilities through conflicts of interest inherent in these contracts, particularly as regarding incentives for and against finding permanent homes for abused and neglected children. Finally, I propose an evidence-based strategy to ameliorate conflicts of interest when making permanent placement decisions for foster children. (shrink)

In 1984, Danecki proved that satisfiability in IPDL, i.e., Propositional Dynamic Logic (PDL) extended with an intersection operator on programs, is decidable in deterministic double exponential time. Since then, the exact complexity of IPDL has remained an open problem: the best known lower bound was the ExpTime one stemming from plain PDL until, in 2004, the first author established ExpSpace-hardness. In this paper, we finally close the gap and prove that IPDL is hard for 2-ExpTime, thus 2-ExpTime-complete. We then sharpen (...) our lower bound, showing that it even applies to IPDL without the test operator interpreted on tree structures. (shrink)

The right to teach at university is a distinctive philosophical and legal conundrum but a largely unexplored question. Drawing on Humboltdian principles, the legitimacy of the university teacher stems from their continuing engagement in research rather than possession of academic and teaching qualifications alone. This means that the right to teach needs to be understood as a privilege and implies that it is always provisional, requiring an ongoing commitment to research. Yet, massification of higher education systems internationally has led to (...) the disaggregation of the academic profession with teaching-only positions now increasingly common. University teachers employed to both teach and research face a narrowing set of performative expectations with respect to how ‘research-active’ is defined. This paper challenges these contemporary understandings and, drawing on historical evidence, argues that a broader definition of research and scholarship needs to underpin the basis of the right to teach. (shrink)

We entered upon the work of last session under the heavy cloud occasioned by the loss of Mr. F. H. Bradley, who died only a few days before its opening at the age of seventy-eight; and, in the midst of that session, on March 4th, Professor James Ward passed away at the ripe age of eighty-two years. Thus the two foremost English philosophers of our time have been removed from our midst; and it seems fitting that, in commencing the duties (...) of this new session, I should say something about their contributions to our common pursuit, and try to indicate what we owe to them who have been for so long the leaders of philosophical research in this country. (shrink)

This is a fine book that sticks with its stated ambition of introducing critical theory. It is meant for Anglo-American philosophers, who have had little interest in and less enthusiasm for, those loosely grouped under the label. Held lays out the details of each critical theorist's work, and avoids the sweeping, provocative slogans that mar other introductory texts. His book's exegesis has more breadth and depth than, say, Schroyer's The Critique of Domination; his work's assessment more balance and support than, (...) say, Slater's Origin and Significance of the Frankfurt School. Held does not match Jay's flair for spotting a unifying theme amid a welter of data. These two authors differ in purpose, however. Jay's outstanding The Dialectical Imagination locates CT broadly within social and political theory, while Held's book situates it more narrowly within the philosophical tradition. (shrink)

G protein‐coupled receptors (GPCRs) are the largest family of transmembrane receptors and primarily signal through two main effector proteins: G proteins and β‐arrestins. Many agonists of GPCRs promote “biased” responses, in which different cellular signaling pathways are activated with varying efficacies. The mechanisms underlying biased signaling have not been fully elucidated, with many potential “hidden variables” that regulate this behavior. One contributor is “location bias,” which refers to the generation of unique signaling cascades from a given GPCR depending upon the (...) cellular location at which the receptor is signaling. Here, we review evidence that GPCRs are expressed at and traffic to various subcellular locations and discuss how location bias can impact the pharmacologic properties and characterization of GPCR agonists. We also evaluate how differences in subcellular environments can modulate GPCR signaling, highlight the physiological significance of subcellular GPCR signaling, and discuss the therapeutic potential of exploiting GPCR location bias. (shrink)

When rates of transcription from specific genes change, delays of variable length intervene before the corresponding mRNAs and proteins attain new levels. For most mammalian genes, the time required to complete transcription, processing, and transport of mRNA is much shorter than the period needed to achieve a new, steady‐state level of protein. Studies of inducible genes have shown that the period required to attain new levels of individual mRNAs and proteins is related to their unique half‐lives. The basis for this (...) is a physical principle that predicts rates of accumulation of particles in compartmental systems. The minimum period required to achieve a new level is directly proportional to product half‐lives because rates of decay control the ratio between the rate of synthesis and the concentration of gene products at steady state. This kinetic model suggests that sensitivity of gene products to degradation by ribonucleases and proteinases is an important determinant of the time scale of gene expression. (shrink)